- I won't stoop down to my level.
- Hello? Bulag ka ba? Bingi ka ba? Are you dep?
- 'Yung STD, baka sa maruming toilet lang niya nakuha yan.
- Eh, ikaw ba naman, durugin ang ari mo... Pag di ka naman manutok ng baril.
- We are lovers, not fighters.
- My brother is not a girl; he's a gentleman.
- That's why I'm a success, it's because I don't middle in other people's lives.
- Don't judge my brother; he's not a book.
- Kapatid ko pa rin siya. We are one and the same.
- I don't eat meat. I'm not a carnival.
- Eto na po ang pinakamaligayang pasko at manigong taon sa inyong lahat.
(During her acceptance speech at a Metro Filmfest awards night where her bioflick, directed by her late father Temyong Marquez, won an award.)
- Sumasakit ang migraine ko.
- Ang tatay ko ang only living legend na buhay!
- Period na talaga; wala nang exclamation point. (When asked on S-Files if her present husband, Adam Lawyer, is her Mr. Right)
- At a talk show after her break-up with Derek Dee, Melanie was asked if she had some words for Derek's mother (whom she partly blamed for the separation)
"Oo nga," said Melanie, "pero i-English-in ko para maintindihan niya.
"She looked into the camera and, with the peremptoriness of royalty, said, "And to you, Mrs. Dee, I have two words for you. Ang labo mo!"
- When asked for a message to her daughter who was allegedly abused by their houseboy:
"Don't worry little angel, big angel is here."
- On what they should do to the houseboy who molested her kid:
"He should be put behind bar."
- "You can fool me once, you can even fool me twice, you can even fool me thrice. But you can never fool me four"
- While waiting backstage during a noontime show, after watching Nikki Valdez do her dance number.
"Nikki, you're so galing. You should go to the States. You will sell hotcakes."
